On June 19, 2010, in game 2 against the New York Yankees of the Subway Series Jose Reyes homerd twice. In the first inning he homered on 0-1 (Solo homerun) count and then in the third on 1-1 count (2-run homer, him and Henry Blanco). Both of them were off pitcher Phil Hughes. Even though the Mets lost to a score of 3-5.
|68||June 19||@ Yankees||3–5||Hughes (10–1)||Pelfrey (9–2)||Rivera (16)||49,073||39–29||Box|