On June 19, 2010, in game 2 against the New York Yankees of the Subway Series Jose Reyes homerd twice. In the first inning he homered on 0-1 (Solo homerun) count and then in the third on 1-1 count (2-run homer, him and Henry Blanco). Both of them were off pitcher Phil Hughes. Even though the Mets lost to a score of 3-5.

68 June 19 @ Yankees 3–5 Hughes (10–1) Pelfrey (9–2) Rivera (16) 49,073 39–29 Box

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