The Mets began the new year of redemption as the Mets started the season with the NL East rival the Flordia Marlins. They won to a score of 7-1 on Opening Day on April 5, 2010. The Mets best month of the year as they had a record of 14-9.

1 April 5 Marlins 7–1 Santana (1–0) Johnson (0–1) 41,245 1–0 Box

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